Category Archives: Xanax

Xanax what category

Anxiety is often associated with depressive disorders
at all levels of severity and it may be difficult to
distinguish between the two conditions, especially in
the milder forms.

Doses of up to 10 mg of alprazolam daily have been
used in the treatment of panic attacks. A modifiedrelease
preparation of alprazolam is also available for
once-daily dosing.

Mixed anxiety and depressive disorder
defines a state in which anxiety and depressive
symptoms coexist but neither component is severe
enough to merit classification as an anxiety disorder
or a depressive disorder.

Xanax pfizer

XANAX, alprazolam tablets, USP


 
CIV DESCRIPTION XANAX

Tablets contain alprazolam which is a triazolo analog of the 1,4 benzodiazepine
class of central nervous system-active compounds.

The chemical name of alprazolam is 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo [4,3-α] [1,4]
benzodiazepine.
The structural formula is represented to the right:

Alprazolam is a white crystalline powder, which is soluble in methanol or ethanol but which has no appreciable solubility in water at physiological pH.
Each XANAX Tablet, for oral administration, contains 0.25, 0.5, 1 or 2 mg of alprazolam. XANAX Tablets, 2 mg, are multi-scored and may be divided as shown below:

Inactive ingredients: Cellulose, corn starch, docusate sodium, lactose, magnesium stearate, silicon dioxide and sodium benzoate. In addition, the 0.5 mg tablet contains FD&C Yellow
No. 6 and the 1 mg tablet contains FD&C Blue No. 2.

Alprazolam and its metabolites are excreted primarily in the urine.

  • Race — Maximal concentrations and half-life of alprazolam are approximately 15% and 25%
    higher in Asians compared to Caucasians.
  • Pediatrics — The pharmacokinetics of alprazolam in pediatric patients have not been studied.
  • Gender — Gender has no effect on the pharmacokinetics of alprazolam.
  • Cigarette Smoking — Alprazolam concentrations may be reduced by up to 50% in smokers
    compared to non-smokers. 

Anxiety Disorders
XANAX Tablets were compared to placebo in double blind clinical studies (doses up to 4
mg/day) in patients with a diagnosis of anxiety or anxiety with associated depressive
symptomatology. XANAX was significantly better than placebo at each of the evaluation 4
periods of these 4-week studies as judged by the following psychometric instruments:
Physician’s Global Impressions, Hamilton Anxiety Rating Scale, Target Symptoms, Patient’s
Global Impressions and Self-Rating Symptom Scale.
Panic Disorder
Support for the effectiveness of XANAX in the treatment of panic disorder came from three
short-term, placebo-controlled studies (up to 10 weeks) in patients with diagnoses closely
corresponding to DSM-III-R criteria for panic disorder.
The average dose of XANAX was 5-6 mg/day in two of the studies, and the doses of XANAX
were fixed at 2 and 6 mg/day in the third study. In all three studies, XANAX was superior to
placebo on a variable defined as "the number of patients with zero panic attacks" (range, 37-
83% met this criterion), as well as on a global improvement score. In two of the three studies,
XANAX was superior to placebo on a variable defined as "change from baseline on the
number of panic attacks per week" (range, 3.3-5.2), and also on a phobia rating scale. A
subgroup of patients who were improved on XANAX during short-term treatment in one of
these trials was continued on an open basis up to 8 months, without apparent loss of benefit.

XANAX Tablets are contraindicated in patients with known sensitivity to this drug or other
benzodiazepines. XANAX may be used in patients with open angle glaucoma who are
receiving appropriate therapy, but is contraindicated in patients with acute narrow angle
glaucoma.
XANAX is contraindicated with ketoconazole and itraconazole, since these medications
significantly impair the oxidative metabolism mediated by cytochrome P450 3A (CYP3A)
(see WARNINGS and PRECAUTIONS–Drug Interactions).

For all users of XANAX:
To assure safe and effective use of benzodiazepines, all patients prescribed XANAX should be
provided with the following guidance.  
1. Inform your physician about any alcohol consumption and medicine you are taking now,
including medication you may buy without a prescription. Alcohol should generally not be
used during treatment with benzodiazepines.
2. Not recommended for use in pregnancy. Therefore, inform your physician if you are
pregnant, if you are planning to have a child, or if you become pregnant while you are taking
this medication.
3. Inform your physician if you are nursing.
4. Until you experience how this medication affects you, do not drive a car or operate
potentially dangerous machinery, etc.
5. Do not increase the dose even if you think the medication "does not work anymore" without
consulting your physician. Benzodiazepines, even when used as recommended, may produce
emotional and/or physical dependence.
6. Do not stop taking this medication abruptly or decrease the dose without consulting your
physician, since withdrawal symptoms can occur.

HOW SUPPLIED
XANAX Tablets are available as follows:
0.25 mg (white, oval, scored, imprinted “XANAX 0.25”)
Bottles of 100  NDC 0009-0029-01
Reverse Numbered
  Unit dose (100) NDC 0009-0029-46
Bottles of 500  NDC 0009-0029-02
Bottles of 1000  NDC 0009-0029-14
0.5 mg (peach, oval, scored, imprinted “XANAX 0.5”)
Bottles of 100  NDC 0009-0055-01
Reverse Numbered
  Unit Dose (100) NDC 0009-0055-46
Bottles of 500  NDC 0009-0055-0322
Bottles of 1000  NDC 0009-0055-15
1 mg (blue, oval, scored, imprinted “XANAX 1.0”)
Bottles of 100  NDC 0009-0090-01
Bottles of 500  NDC 0009-0090-04
Bottles of 1000  NDC 0009-0090-13
2 mg (white, oblong, multi-scored, imprinted “XANAX ” on one side and “2” on the reverse
side)
Bottles of 100  NDC 0009-0094-01
Bottles of 500  NDC 0009-0094-03
Store at controlled room temperature 20° to 25°C (68° to 77°F) [see USP].
Rx only

What is Xanax  (alprazolam) ?

Xanax (alprazolam) belongs to a group of drugs called benzodiazepines. It works by slowing down the movement of chemicals in the brain that may become unbalanced. This results in a reduction in nervous tension (anxiety). Xanax is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

Xanax may also be used for purposes not listed in this medication guide.  Important information about Xanax Do not use Xanax if you are pregnant.

It could harm the unborn baby. Do not use Xanax if you are allergic to alprazolam or to other benzodiazepines, such as chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).

Video: Treatment for Depression   Treatments for depression are getting better everyday and there are things you can start doing right away. Before you take Xanax, tell your doctor if you have asthma or other breathing problems, glaucoma, kidney or liver disease, a history of alcoholism, or a history of depression, suicidal thoughts, or addiction to drugs or alcohol. Do not drink alcohol while taking Xanax. This medication can increase the effects of alcohol.

Xanax may be habit-forming and should be used only by the person for whom it was prescribed. Keep the medication in a secure place where others cannot get to it.  Before taking Xanax It is dangerous to try and purchase Xanax on the Internet or from vendors outside of the United States. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Samples of Xanax purchased on the Internet have been found to contain haloperidol (Haldol), a potent antipsychotic drug with dangerous side effects. For more information, contact the U.S.

Food and Drug Administration (FDA)

 You should not take Xanax if you have: narrow-angle glaucoma; if you are also taking itraconazole (Sporanox) or ketoconazole (Nizoral); or if you are allergic to alprazolam or to other benzodiazepines, such as chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax). To make sure you can safely take Xanax, tell your doctor if you have any of these other conditions: asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems; glaucoma; kidney or liver disease (especially alcoholic liver disease); a history of depression or suicidal thoughts or behavior; or a history of drug or alcohol addiction. Xanax may be habit forming and should be used only by the person for whom it was prescribed.

Do not use Xanax if you are pregnant.

Never share Xanax with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. FDA pregnancy category D. Do not use Xanax if you are pregnant. It could harm the unborn baby.

Xanax may also cause addiction or withdrawal symptoms in a newborn if the mother takes the medication during pregnancy. Use effective birth control, and tell your doctor if you become pregnant during treatment. Alprazolam can pass into breast milk and may harm a nursing baby.

You should not breast-feed while you are using this medicine. The sedative effects of Xanax may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking Xanax.

Do not give this medication to anyone under 18 years old. How should I take Xanax? Take Xanax exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results. Do not crush, chew, or break a Xanax extended-release tablet. Swallow the tablet whole. It is specially made to release medicine slowly in the body.

Breaking the tablet would cause too much of the drug to be released at one time. Contact your doctor if this medicine seems to stop working as well in treating your panic or anxiety symptoms. You may have seizures or withdrawal symptoms when you stop using Xanax. Ask your doctor how to avoid withdrawal symptoms when you stop using Xanax. Keep track of the amount of medicine used from each new bottle.

Xanax is a drug

Xanax is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription. Store Xanax at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose.

Do not take extra medicine to make up the missed dose.  What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Xanax can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, and fainting. What should I avoid while taking Xanax? Do not drink alcohol while taking Xanax.

This medication can increase the effects of alcohol. Xanax may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Grapefruit and grapefruit juice may interact with Xanax and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.